PGT-M Testing
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What is PGT-M Testing?
Preimplantation genetic testing for monogenic disorders is a terminology referred to as PGT-M, which means the screening process involving genetics to detect single-gene disorders among embryos. Such conditions include cystic fibrosis, sickle cell anemia, Huntington's disease, and others. This technique allows embryos that are carrying genetic defects to be identified through testing, and only those not suffering from the defect can be transferred with the process of IVF.
This testing particularly benefits the couples that come with a family history of genetic disorders. This would reduce their anxiety level since it reduces the chance of inherited disorders being transmitted to the child, providing peace of mind to the couple.
Why is PGT-M Done?
PGT-M is done to screen embryos for specific single-gene (monogenic) disorders before transfer, so couples at risk can have unaffected children.
What Does PGT-M Check?
PGT-M checks embryos for:
How is PGT-M Performed?
PGT-M is performed during an IVF cycle:
Parents' blood/saliva is used to identify the mutation and linked markers (probes).
Embryos are created and grown to blastocyst stage (day 5–6).
A few cells are removed from each embryo for genetic testing.
Cells are tested for the specific mutation; unaffected embryos are identified for transfer.
How to Prepare for PGT-M
Pre-test work-up (parent samples and probe design) is required. You will then undergo an IVF cycle. Your doctor and genetic counselor will guide you through timing and consent.
Understanding PGT-M Results
Results show which embryos carry the mutation and which do not. Only embryos free of the tested disorder are recommended for transfer. PGT-M success rate depends on embryo quality and IVF outcome; our team will explain your results and next steps.
Cost of PGT-M
PGT-M testing cost in India typically ranges from ₹50,000 to ₹1,50,000 depending on complexity and number of embryos. Contact us for current pricing and to book an appointment.