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HLA Matching in IVF

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What is HLA Matching?

This is a test that identifies genetic markers residing in the immune system. Such markers will enable the body to recognize its cells and differentiate between those are its cells and those that are foreign. From an IVF context, HLA matching serves as a method to assess compatibility between the mother, father, and embryo and can be used to predict the success of implantation and pregnancy.

Why is HLA Matching in IVF Done?

HLA matching is especially important in IVF because:

It reduces the risk of implantation failure.
It prevents the immune system from rejecting the embryo.
It increases the success and healthy possibility of a pregnancy.
This has minimized complications of recurrent miscarriages or pregnancy loss

Why is HLA Matching in IVF Done?

HLA matching is done to assess immune compatibility between parents and/or embryos in IVF, and to select embryos for saviour sibling or HLA-matched transplant when needed.

Assess compatibility for implantation and pregnancy success
Reduce risk of immune-mediated implantation failure or loss
HLA-matched embryo selection when a sibling needs stem cell transplant (saviour sibling)

What Does HLA Matching in IVF Check?

HLA matching checks:

HLA (human leukocyte antigen) markers in parents and/or embryos
Compatibility between mother, father, and embryo
HLA type of embryos when matching for a sick sibling is required

How is HLA Matching in IVF Performed?

The HLA matching process typically involves:

1. Sample collection

Blood or cheek swab samples are collected from both parents (and sometimes from the child needing transplant).

2. Laboratory testing

Samples are tested to determine HLA markers.

3. Matching and reporting

A matching report evaluates compatibility or identifies HLA-matched embryos (e.g. with PGT and HLA typing).

4. Treatment plan

Based on results, a personalized IVF/treatment plan is designed.

How to Prepare for HLA Matching in IVF

Usually no special preparation for blood or cheek swab. If combined with IVF/PGT, follow standard IVF and PGT-M/HLA work-up as advised by your doctor.

Understanding HLA Matching in IVF Results

Results indicate HLA compatibility or which embryos are HLA-matched. Our team will explain how this affects your IVF plan, implantation success, or saviour sibling options.

Cost of HLA Matching in IVF

HLA matching test cost in India typically ranges from ₹10,000 to ₹30,000 depending on test type and clinic. Contact us for pricing and to book an appointment.